Use our interactive PK Modeling Tool to predict FIX activity of Rebinyn® compared with standard half-life (SHL) factor IX products. See plasma activity, WFH target factor IX levels, total dosage, and total infusions required for a range of bleed types: mild to moderate, severe, surgical use, or intracranial hemorrhages.
COMPARATIVE PK DATA: REBINYN® vs. OTHER FACTOR IX PRODUCTS

Considering FIX treatment options? Rebinyn® may provide higher factor levels for longer.

COMPARE THE IMPROVED PK PROFILE OF REBINYN®


COMPARATIVE PK DATA: REBINYN® vs. OTHER FACTOR IX PRODUCTS

Considering FIX treatment options? Rebinyn® may provide higher factor levels for longer.

WFH=World Federation of Hemophilia

COMPARED WITH SHL, A SINGLE DOSE OF REBINYN® WAS PREDICTED TO CONTROL A MILD TO MODERATE BLEED


A single 40 IU/kg dose of Rebinyn®, was predicted to provide FIX levels above 40% for an average of 23 hours using PK simulations.1



1 dose of Rebinyn® vs 2 doses of SHL rFIX or pdFIX were required to maintain the same WFH target FIX activity level.1
WFH=World Federation of Hemophilia
COMPARED WITH SHL, A SINGLE DOSE OF REBINYN® WAS PREDICTED TO CONTROL A SEVERE BLEED


A single 80 IU/kg dose of Rebinyn® was predicted to provide FIX levels above 50% for an average of 3 days using PK simulations.1



1 dose of Rebinyn® vs 6 doses of SHL rFIX or pdFIX were required to maintain the same WFH target FIX activity level.1
WFH=World Federation of Hemophilia
COMPARED WITH SHL, AN INITIAL DOSE OF REBINYN® WAS PREDICTED TO MAINTAIN FIX LEVELS IN SURGERY


A single 80 IU/kg dose of Rebinyn®, followed by two 40 IU/kg doses, was predicted to maintain target FIX levels for a 2-week postoperative period using PK simulations.1



3 doses of Rebinyn® vs 17 doses of SHL rFIX or pdFIX were required to maintain the same WFH target FIX activity level.1
WFH=World Federation of Hemophilia
COMPARED WITH SHL, FEWER DOSES OF REBINYN® WERE PREDICTED TO CONTROL FIX LEVELS IN INTRACRANIAL HEMORRHAGE


A single 80 IU/kg dose of Rebinyn®, followed by four 40 IU/kg doses, was predicted to maintain target FIX levels for a 3-week postoperative period using PK simulations.1


5 doses of Rebinyn® vs 28 doses of SHL rFIX or pdFIX were required to maintain the same WFH target FIX activity level.1
WFH=World Federation of Hemophilia
Use our interactive PK Modeling Tool to predict FIX activity of Rebinyn® compared with an extended half-life (EHL) factor IX product. See plasma activity, WFH target factor IX levels, total dosage, and total infusions required for a range of bleed types: severe, surgical use, or life-threatening bleeds.
WFH=World Federation of Hemophilia

COMPARED WITH EHL rFIXFc, A SINGLE DOSE OF REBINYN® WAS PREDICTED TO CONTROL A SEVERE BLEED


A single 80 IU/kg dose of Rebinyn® was predicted to provide FIX levels above 50% for an average of ≈5 days using PK simulations.2

1 dose of Rebinyn® vs 4 doses of EHL rFIXFc were required to maintain the same WFH target FIX activity level.2
WFH=World Federation of Hemophilia
COMPARED WITH EHL rFIXFc, AN INITIAL DOSE OF REBINYN® WAS PREDICTED TO MAINTAIN FIX LEVELS IN SURGERY


A single 80 IU/kg dose of Rebinyn®, followed by two 40 IU/kg doses, was predicted to maintain target FIX levels for a 2-week postoperative period using PK simulations.2

3 doses of Rebinyn® vs 9 doses of EHL rFIXFc were required to maintain the same WFH target FIX activity level.2
WFH=World Federation of Hemophilia
COMPARED WITH EHL rFIXFc, FEWER DOSES OF REBINYN® WERE PREDICTED TO CONTROL FIX LEVELS IN LIFE-THREATENING BLEEDS


A single 80 IU/kg dose of Rebinyn®, followed by four 40 IU/kg doses, was predicted to maintain target FIX levels for a 3-week postoperative period using PK simulations.2

5 doses of Rebinyn® vs 11 doses of EHL rFIXFc were required to maintain the same WFH target FIX activity level.2
WFH=World Federation of Hemophilia
REBINYN® MAY REDUCE THE NEED FOR ADDITIONAL INFUSIONS1,2,a-c


Based on pharmacokinetic (PK) modeling, Rebinyn® required fewer infusions per episode when compared with SHL and EHL FIX products.
Estimated number of doses and amount of FIX per episode1,2,a-c

aA single dose should be sufficient for minor and moderate bleeds. Additional doses of 40 IU/kg can be given.3
bBased on PK modeling to World Federation of Hemophilia (WFH) guidelines. Simulated results based on phase 1 PK studies of Rebinyn® (n=30), recombinant FIX (rFIX) (n=7), and plasma-derived FIX (pdFIX) (n=8), and rFIXFc (n=15).1
cBased on PK modeling to WFH guidelines. Simulated results based on phase 1 PK study of Rebinyn® (n=15).2
HIGH FACTOR ACTIVITY

Studies show Rebinyn® elevates factor levels.2
IS REBINYN® RIGHT FOR YOUR PATIENTS?

Our FIX comparison guide highlights storage conditions and more.
HIGH FACTOR ACTIVITY
Studies show Rebinyn® elevates factor levels.2
IS REBINYN® RIGHT FOR YOUR PATIENTS?
Our FIX comparison guide highlights storage conditions and more.
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